Aim: to assess the incidence of sexual side effects following medical treatment of BPH in Indian population. Materials and methods: The present observational study was conducted in the department of Urology, Indira Gandhi Institute of Medical Sciences Sheikhpura, Patna, from January 2018 - June 2019 among 120 patients diagnosed with BHP. Patients diagnosed with symptomatic BPH and willing for medical treatment were included in this study. Patients received either of following medical treatment: Tamsulosin 0.4 mg once a day (qd),/Silodosin 4-8 mg qd,/Alfuzosin SR 10 mg qd,/combination of Dutasteride 0.5 mg PO qd and Silodosin 4-8 mg qd Results: Out of total 120; 7 were given Alfuzosin; 24 were treated with Tamsulosin; 41 were with Silodosin and rest 48 were given combination of Silodosin & dutasteride. 2 patients couldn’t have sexual intercourse due to ED. 8 out of the 39 patients (20.5%) treated with silodosin 8mg who could have sexual intercourse., complained of EjD.3 out of the 41 patients (7.3%) treated with silodosin and dutasteride, who could have sexual intercourse could not achieve orgasm. Conclusion: The incidence of sexual dysfunction is least with Alfuzosin. Among drug treatment-combination therapy is associated with maximum incidence of sexual dysfunction in comparison to drugs used alone.