Background:High serum amylase is frequently found in perforated duodenal ulcer (PDU),the rise in serum amylase occurs in cases of perforated peptic ulcer partly as a result of increase leakage of pancreatic enzymes rich fluid from the perforation site with subsequent absorption by peritoneal lymphatics & partly due to damage of pancreases by digestive enzymes that spilled through the perforation. Interestingly, the start of these trends all predated the use of H2 receptor blockers, or proton pump inhibitors, fibre optic endoscopy, and highly selective vagotomy. However, the incidence of emergency surgeryand the death rate associated with peptic ulcers has not decreased nearly so dramatically. Aims and objectives: The purpose of this study is to study signs, symptoms, mode of presentation and post operative complications associated with duodenal perforation and importantly to assess the Serum Amylase levels in duodenal perforation and correlate the levels with post operative complications.