Background:Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and in intensity, together with variable expiratory airflow limitation. AIM: To estimate the pro inflammatory cytokine (TNFα), anti-inflammatory cytokine (IL-10) and serum IgE levels during exacerbation and remission of asthma and to compare with normal controls