Aim: The purpose of this finite element analysis (FEA) was to compare and evaluate the fracture resistance and stress distribution of endodontically treated teeth restored with endocrown in different materials and types of luting cement. Material and Methods:Four endodontically treated teeth first mandibular molar restored with an endocrown was modeled by using CAD software and imported into an FEA software. The models were duplicated and the first model received restoration in lithium disilicate with RelyXUltimate (3M ESPE USA) cement, the second model in lithium disilicate with Panavia F 2.0 (Kuraray Noritake), the third model in zirconia with RelyX Ultimate (3M ESPE USA) and fourth model in zirconia with Panavia F 2.0 (Kuraray Noritake). Stress distribution under axial (90o ) and non-axial degree(0o and 45o ) by loading 225 Newton (mastication force) and 600 Newton (biting force) were analyzed. Results were determined by colorimetric von mises of maximum total deformation, equivalent elastic strain, and equivalent stress on a tooth, cement, and restoration.The results indicated that zirconia endocrown with Rely X and Panavia F.20 cement has better fracture resistance than the other model.The critical area of total deformation and the equivalent elastic strain was on the occlusal and the equivalent stress was in the cementdentin interface.