Abstract: Tay-Sachs disease (TSD) is a fatal genetic disorder that causes progressive destruction of the nervous system. It also affects the mental and physical abilities of that being around six month of age. TSD most commonly occurs in children that causes the slow destruction of the central nervous system.. It occurs when more quantities of cell membrane components called gangliosides, accumulate in the brain’s nerve cells. This occurs due to the absence of an important enzyme called Hexosaminidase-A (HEXA)