Vishamjwara is the special type of Jwara which is explained in all classical text of Ayurveda. Vishamjwara is classified according to its onset of duration and its clinical presentation regarding specific sites. Bhel samhita is one of the ancient ayurvedic text. Maharshi “Bhel” is one of the six students of Atreya Punarvasu. Some chapters of Bhelsamhita are missing but remaining chapters are very informative. Vishamjwara chikitsa is one of them. Bhel samhita elaborated Vishamjwara samprapti according to involvement of specific dosha-dushyas on successive days which is very unique and different explanations than other ayurvedic samhita. These vishamjwara samprapti lakshanas shows resemblance to cytokinin release symptoms which occur in malaria.So, Bhel samhita provide a new aspect regarding cytokine release syndrome (CRS) in terms of ayurveda.