Abstract: Hydrazide-hydrazones derivatives are available in numerous bioactive atoms and show a wide variety of biological activities, like antibacterial, antitubercular, antifungal, anticancer, mitigating, anticonvulsant, antiviral and antiprotozoal activity. In this manner numerous researchers synthesised different hydrazide-hydrazones and assess them for their activity. This paper is centred on the overview of the literature finding of the last 15 years covering the research on antimicrobial, anticancer and anticonvulsant of hydrazide-hydrazones derivatives.