Background:The aim of the study is to compare induction with etomidate and propofol on hemodynamic response to laryngoscopy and intubation. Materials and Methods: The study was conducted in 60 ASA I & II patients in the age group of 18 to 60 years who were posted for elective surgeries under general anaesthesia. Their baseline heart rate, systolic blood pressure, diastolic blood pressure, SpO2 and ETCO2 were recorded. Both the groups were premedicated with iv glycopyrrolate 5mcg/kg, iv midazolam 0.025mg/Kg, iv fentanyl 2mcg/Kg. Following premedication, the above variables were again recorded. Group P patients were induced with iv propofol at the dose of 2 mg/Kg and Group E patients received iv etomidate at 0.4mg/Kg. In both the groups, Injection vecuronium was given at the dose 0.08mg/Kg and they were maintained with O2:N2O =33%:66% and Isoflurane 1% dial concentration. Laryngoscopy was performed by trained anesthesiologists after 5 mins. Duration of laryngoscopy was kept at a maximum of 10 seconds. Trachea was intubated with appropriate size endotracheal tube. The variables (HR, SBP, DBP, MAP, SpO2) were measured during induction, intubation and post intubation at intervals of 1,2,3,5 and 10 mins.