Aim: The aim of this study to analyzed antimicrobial Resistance Pattern of Bacteria Isolated from ICU Patients with Respiratory Tract Infections. Materials and Methods: This was a prospective, observational study conducted in the Department of Anaesthesia , ICARE Institute of Medical Science and Research &Dr.Bidhan Chandra Roy Hospital, Haldia,West Bengal, India. A total of 200 samples (Sputum, Pleural fluid, Pus, IT-Tube sample, Bronchial swab, Respiratory swab) of RTI patients were collected from Respiratory ICU. For identification of different microorganisms selective media were used in this study. Isolate the microorganisms with the help of primary and secondary identification and antibiotic sensitivity were performed. Results: Majority of the patients was male 62.5% and rest 37.5% was female. Gram negative organisms are detected in (67%), Gram positive organisms detected (22%), and no organism detected (11%) of the swab samples. Conclusion: Piperacillin-tazobactam was the most common antibiotic prescribed to patients with respiratory infection admitted to ICU. More than half of patients had resistance to the empirical antibiotic used in our ICU, highlighting the need for antibiogram for each ICU. Most of the patient had prior antibiotic use and had mainly gram negative organisms with high resistance to commonly used antibiotics.