Background: Nowadays laparoscopic surgery is going to be the first choice for surgical management of various indications, especially with the well-trained laparoscopic surgeon. The benefits of minimal access techniques include less pain, early mobilization, shorter hospital stay, and better cosmetic results, which have further increased its applications. The aim of this study to compare the efficacy of intravenously administered clonidine and magnesium sulfate on hemodynamic stress response during laparoscopic surgeries.