Fluoroscope-guided percutaneous closure is the preferable technique in children with patent ductus arteriosus (PDA). A prospective randomized case control study was performed in children between 6 months -12 years in our institution to compare the radiation exposure and procedural time of PDA device closure by transthoracic echocardiography with the use of minimal fluoroscopy(case) to conventional method(control). Post-operative follow-up for six-month was done. Among 106 patients, 51 patients were case and 51 patients were control. There was a significant difference between the fluoroscopy time, procedural time, and amount of radiation exposure in terms of total air kerma, dose area product and dose area product/kg among the case and control group. p< 0.001 was considered significant. The result shows that PDA device closure with transthoracic echocardiography-guidance with minimal fluoroscopy as compared to the conventional method reduces radiation exposure, procedural time and complications related to arterial access.