Introduction: Soft tissue defects are more commonly seen in the extremities following high velocity trauma & occupational injuries posing countless challenges in their management. Early flaps or skin grafts reduce the chance of infections in the soft tissue defects. Both are done after thorough surgical debridement. In some cases wound related and patient related factors won’t allow early coverage of these defects. During which, one has to consider alternative methods of managing the soft tissue defects in the primary set up. One of the available modality for managing soft tissue defects in the initial periods is Negative Pressure Wound Therapy. This has been found to have a vast benefit over conventional dressings like tulle grass and others. This present study has been conducted in our hospital which is a tertiary care centre, to evaluate the efficacy of Negative Pressure Wound Therapy (NPWT) in the management of soft tissue defects in the extremities over the conventional method of managing the wounds with chlorhexidine dressing