Background: Microbial infections are commonest in surgical scenarios all over the world. These are easily treatable using antibiotic therapy. They have been classified variously mainly based upon their mechanisms of action, route of administration and methods of synthesis. However, they are routinely related to side-effects and adverse drug reactions. Objectives: This was a comparative study between Ceftriaxone and Ceftriaxone with Sulbactam combination for controlling post-operative infections arising in surgical units. Objectives were- a) to compare complications arising due to both the drug therapies; b) Reduction in morbidity and mortality and c) Reduce the overall treatment cost which may arise due to complications occurring. Methods: Total of 100 subjects were categorized into two groups comprising of 50 participants each- a) Group I (Ceftriaxone alone) and b) Group II (Ceftriaxone with Sulbactam, combination). Patients were examined in following durations: i) Immediately after surgery; ii) 3 rd day, iii) 7th day, iii) 15th day and iv) One month post-operative period for complications. Result: Group II drug combination demonstrated lesser incidence of post-operative complications when compared with group I most specifically, pus formation, septicemia, wound gapping, Skin necrosis, incisional hernias, shock, chills, hematuria, urinary infection and burning sensation during micturition. No cases of multiple organ failure or death were reported. Conclusion: Though there were less or no incidence of complications in Group II compared to group I, no statistical significant difference could be determined. Thus, it can be concluded that a large sample size would reflect clearly on clear distinction between the drugs/drug combinations studied.