Introduction: Psoriasis is a chronic skin disease of unclear aetiology and pathogenesis which is characterized by an inflammatory infiltration in dermis and epidermis, proliferation of epidermal cells – keratinocytes which clinically manifests with the formation of erythemato-squamose papules, and is often accompanied by the engagement of joints and nails in the process of inflammation. Materials and Methods: This is a case-control study conducted at Department of Biochemistry, Central Research Lab and Central Clinical Lab of GMC Azamgarh. The subjects will be selected as per the inclusion/ exclusion criteria. A detailed clinical history including age, sex, and occupation will be collected from the patients after obtaining written and informed consent. For ApoE: Genomic Dna is extracted from blood using QIAamp DNA minikit. The genotypes of the APOE polymorphisms is determine by using APOE strip assay kit based on polymerase chain reaction and reverse-hybridization technique.