ISSN 2515-8260
 

Research Article 


Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel.

Abstract
Purpose - To evaluate what effect spreading the maintenance BCG regimen from 12 to 18 months has on the treatment completion rate.
Patients and methods - Retrospective data about patients diagnosed with intermediate or high risk nonmuscle invasive bladder cancer were collected. Suggested regimen started with 6 weekly induction intravesical full dose BCG instillations followed by 3 weekly instillations, 3 months after the 6th instillation. Thereafter, 3 weekly instillations were delivered 6 months after the 9th and the 12th instillation. In total, 15 BCG instillations were administered within 18 months. Cystoscopy and urine cytology were performed one month following the 6th, 9th, 12th and 15th instillations and then according to guidelines
Results - 195 patients met the inclusion criteria. 190 (97.4%) patients completed the induction instillations and 141 (72.3%) completed the treatment protocol. 39 patients discontinued treatment for medical reasons and 15 patients due to non-compliance. 162 patients completed follow up as recommended for a median of 4620.1 months. Of those, 45 patients (27.8%) and 8 (4.9%) had disease recurrence and progression, respectively.
Conclusion - Spreading BCG instillations during maintenance protocol might achieve a better treatment completion rate, mainly due to improved patient compliance. No impacts on recurrence and progression rates have been observed in our cohort. Prospective randomized trials are warranted before suggesting clinical application.

Key words: Non-muscle invasive bladder cancer; Maintenance BCG irrigations; Completion rate; Treatment sreading; Compliance


 
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How to Cite this Article
Pubmed Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel. Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. EJMCM. 2020; 7(1): 30-34.


Web Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel. Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. http://www.ejmcm.com/?mno=9335 [Access: July 03, 2020].


AMA (American Medical Association) Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel. Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. EJMCM. 2020; 7(1): 30-34.



Vancouver/ICMJE Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel. Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. EJMCM. (2020), [cited July 03, 2020]; 7(1): 30-34.



Harvard Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel (2020) Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. EJMCM, 7 (1), 30-34.



Turabian Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel. 2020. Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. European Journal of Molecular & Clinical Medicine, 7 (1), 30-34.



Chicago Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel. "Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months." European Journal of Molecular & Clinical Medicine 7 (2020), 30-34.



MLA (The Modern Language Association) Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel. "Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months." European Journal of Molecular & Clinical Medicine 7.1 (2020), 30-34. Print.



APA (American Psychological Association) Style

Rani Zreik, Boris Friedman, Nitza Hirshberg, Gal Rinott Mizrahi, Yael Hod, Ghazi Fari, Freifeld Yuval, Avi Stein, Yoram Dekel (2020) Improvement of adherence to treatment in patients with nonmuscle invasive bladder cancer (NMIBC) by spreading the 12 months maintenance Bacillus Calmette-Guerin (BCG) regimen over 18 months. European Journal of Molecular & Clinical Medicine, 7 (1), 30-34.